Isuzumabumenyi ryerekana akazi kuri 4,4′-methylene-bis- (2-chloroaniline) “MOCA” hakoreshejwe uburyo bushya bworoshye bwo gukurikirana ibinyabuzima

Uburyo bushya bwo gusesengura ibintu, bwaranzwe nuburyo bwihariye hamwe nubukangurambaga bukomeye, bwateguwe neza kugirango hamenyekane 4,4′-methylene-bis- (2-chloroaniline), bakunze kwita “MOCA,” mu nkari z’abantu. Ni ngombwa kumenya ko MOCA ari kanseri yanditswe neza, ifite ibimenyetso byerekana uburozi byemeza ko itera kanseri mu nyamaswa zo muri laboratoire nk'imbeba, imbeba, n'imbwa.

Mbere yo gukoresha ubu buryo bushya bwatunganijwe muburyo busanzwe bwakazi, itsinda ryubushakashatsi ryabanje gukora ubushakashatsi bwigihe gito bwifashishije imbeba. Intego yibanze yubu bushakashatsi bwibanze kwari ukumenya no gusobanura ibintu bimwe na bimwe byingenzi bifitanye isano no gusohora inkari za MOCA mu cyitegererezo cy’inyamaswa - harimo nk'igipimo cyo gusohoka, inzira za metabolike, hamwe n'idirishya ry'ibihe kugira ngo bigaragare - hashyirwaho urufatiro rukomeye rwa siyansi kugira ngo hakurikizwe ubwo buryo mu ngero z'abantu.

Nyuma yo kurangiza no kwemeza ubushakashatsi bwibanze, ubu buryo bwo gushingira ku nkari bwakoreshejwe ku mugaragaro kugira ngo hamenyekane aho akazi gakorerwa MOCA mu bakozi bo mu nganda z’inganda z’Abafaransa. Ubushakashatsi bwakozwe bwerekanye ubwoko bubiri bwingenzi bwibikorwa bifitanye isano ya hafi na MOCA: kimwe cyari uburyo bwo gutunganya inganda za MOCA ubwacyo, ikindi ni ugukoresha MOCA nk'umuti ukiza mu gukora elastomeri ya polyurethane, ibintu bisanzwe bikoreshwa mu nganda z’imiti n’ibikoresho.

Binyuze mu igeragezwa rinini ry’ingero z’inkari zegeranijwe n’abakozi muri ibi bihe, itsinda ry’ubushakashatsi ryerekanye ko urwego rwo gusohora inkari za MOCA rwerekanye ibintu byinshi bitandukanye. By'umwihariko, imyunyu ngugu isohoka kuva ku rwego rutamenyekana - bisobanurwa ko ari munsi ya microgramu 0,5 kuri litiro - kugeza kuri microgramo 1.600 kuri litiro. Byongeye kandi, iyo N-acetyl metabolite ya MOCA yari ihari mu byitegererezo by’inkari, intumbero zabo zahoraga kandi ziri hasi cyane ugereranije n’ubushakashatsi bw’ababyeyi (MOCA) mu ngero zimwe, byerekana ko MOCA ubwayo aribwo buryo bwambere busohoka mu nkari kandi ni ikimenyetso cyizewe cyo kwerekana.

Muri rusange, ibisubizo byabonetse muri iri suzuma rinini ryagaragaye ku kazi byagaragaye ko bigaragara neza kandi neza mu buryo rusange urwego rwa MOCA rwerekanwe ku bakozi bakoreweho ubushakashatsi, kubera ko urwego rwasohotse rusohokana rwari rufitanye isano rya bugufi n'imiterere y'akazi kabo, igihe bamaraga, ndetse n'ibidukikije bikora. Byongeye kandi, ikintu cyingenzi cyagaragaye muri ubwo bushakashatsi ni uko nyuma y’isesengura ry’isesengura rirangiye kandi hagamijwe ingamba zo gukumira zashyizwe mu bikorwa ku kazi - nko kunoza uburyo bwo guhumeka, kuzamura ibikoresho by’umuntu ku giti cye (PPE), cyangwa kunoza imikorere y’ibikorwa - urwego rwo gusohora inkari za MOCA mu bakozi bahuye nacyo akenshi rwerekanaga igabanuka rigaragara kandi rikomeye mu kugabanya ingaruka z’akazi kuri MOCA.