Glutaraldehyde Imipaka Yikoranabuhanga: Iterambere muri Tekinoroji yo Kurwanya

Mu rwego rwo gutera umutima-mitsi, glutaraldehyde imaze igihe kinini ikoreshwa mu kuvura ingirangingo z’inyamaswa (nka bovine pericardium) kugira ngo habeho umusaruro wa bioprosthetic. Nyamara, ibisigisigi byubusa bya aldehyde biva mubikorwa gakondo birashobora kuganisha kumibare nyuma yo guterwa, bikabangamira igihe kirekire cyibicuruzwa.

Kugira ngo iki kibazo gikemuke, ubushakashatsi buherutse gusohoka muri Mata 2025 bwatangije igisubizo gishya cyo kuvura imiti (izina ry'ibicuruzwa: Periborn), kigera ku majyambere adasanzwe.

1.Iterambere rya tekinoroji:

Iki gisubizo gitangiza byinshi byingenzi kunoza imikorere ya glutaraldehyde gakondo:

Guhuza ibinyabuzima byambukiranya:
Glutaraldehyde ihuza-bikorwa ikorwa mumashanyarazi kama igizwe na 75% Ethanol + 5% octanol. Ubu buryo bufasha gukuraho neza fosifolipide ya tissue mugihe cyo guhuza-fosifolipide ni urubuga rwambere rwa nucleation yo kubara.

Umwanya-Wuzuza Umwanya:

Nyuma yo guhuza, polyethylene glycol (PEG) ikoreshwa nkibikoresho byuzuza umwanya, byinjira mu cyuho kiri hagati ya fibre ya kolagen. Ibi byombi bikingira ikibanza cya nucleation ya kristu ya hydroxyapatite kandi ikarinda kwinjiza calcium na fosifolipide kuva plasma yakira.

Gufunga Ikirangantego:

Hanyuma, kuvura hamwe na glycine bitesha agaciro amatsinda ya aldehyde yubusa, bityo bikuraho ikindi kintu cyingenzi gitera kubara na cytotoxicity.

2.Kwumva ibisubizo byubuvuzi:

Iri koranabuhanga ryakoreshejwe kuri bovine pericardial scafold yitwa "Periborn." Ubushakashatsi bwakorewe mu mavuriro bukubiyemo abarwayi 352 mu myaka 9 bwerekanye ko bafite umudendezo wo kongera kwisubiraho bitewe n’ibibazo bifitanye isano n’ibicuruzwa bigera kuri 95.4%, byemeza ko ingamba z’ingamba nshya zo kurwanya calcisiyasi ndetse n’igihe kirekire kidasanzwe.

Akamaro k'iri terambere:

Ntabwo ikemura gusa ikibazo kimaze igihe kinini mubijyanye na bioprosthetike, kongerera igihe ubuzima bwibicuruzwa, ariko kandi itera imbaraga nshya mugukoresha glutaraldehyde mubikoresho byo mu rwego rwo hejuru.