Umupaka w'ikoranabuhanga rya Glutaraldehyde: Iterambere mu ikoranabuhanga rirwanya Calcification

Mu rwego rwo gutera imiti itera indwara z'umutima n'imitsi, glutaraldehyde imaze igihe kinini ikoreshwa mu kuvura ingingo z'inyamaswa (nk'inka pericardium) mu gukora valves za bioprosthetic. Ariko, amatsinda ya aldehyde asigaye akomoka ku buryo gakondo ashobora gutuma calcium ikwirakwira nyuma yo gutera imiti, bigatuma ibyo bicuruzwa biramba igihe kirekire.

Mu gukemura iki kibazo, ubushakashatsi buheruka bwasohotse muri Mata 2025 bwagaragaje uburyo bushya bwo kuvura indwara ziterwa na kalisiyumu (izina ry’umuti: Periborn), bugera ku iterambere ritangaje.

1. Ivugurura ry'ingenzi ry'ikoranabuhanga:

Iki gisubizo gitanga uburyo butandukanye bwo kunoza imikorere gakondo ya glutaraldehyde:

Uburyo bwo guhuza ibinyabuzima mu gushonga:
Guhuza imiterere ya Glutaraldehyde bikorwa mu buryo bwa organic solvent bugizwe na 75% ya ethanol + 5% ya octanol. Ubu buryo bufasha mu gukuraho neza phospholipide mu mubiri mu gihe cyo guhuza imiterere y’umubiri—phospholipide ni zo nyubako z’ibanze za calcium.

Umukozi Ushinzwe Kuzuza Ahantu:

Nyuma yo guhuza, polyethylene glycol (PEG) ikoreshwa nk'ikintu cyo kuzuza umwanya, cyinjira mu cyuho kiri hagati y'imigozi ya collagen. Ibi byombi birinda ahantu hashyirwa kristu za hydroxyapatite kandi bikarinda kwinjira kwa kalisiyumu na phospholipide mu maraso y'umuntu.

Gufunga icyuma gifunga:

Amaherezo, kuvura hakoreshejwe glycine bigabanya amatsinda ya aldehyde yigenga kandi asigaye, bityo bigakuraho ikindi kintu cy'ingenzi gitera calciumification na cytotoxicity.

2. Ibisubizo by'ubuvuzi bidasanzwe:

Ubu buryo bwakoreshejwe ku gikoresho cy’inka cyitwa “Periborn.” Inyigo yakozwe ku barwayi 352 bamaze imyaka 9 bagaragaje ko nta kongera kubagwa biturutse ku bibazo bifitanye isano n’ibicuruzwa bigera kuri 95.4%, byemeza ko iyi ngamba nshya yo kurwanya kalisiyumu ikora neza kandi ko iramba cyane mu gihe kirekire.

Akamaro k'iyi ntambwe:

Ntabwo ikemura gusa ikibazo kimaze igihe kinini mu bijyanye n'udupira twa bioprosthetic, yongera igihe cyo kubaho k'umuti, ahubwo inashyira imbaraga nshya mu ikoreshwa rya glutaraldehyde mu bikoresho byo mu rwego rwo hejuru bya biomedical.